Vince Giuliano

Healthy Longevity

Date Aired: February 16, 2018

Episode Description

People are living longer lives than in the past. With the aging of the baby boomers, the percentage of people older than sixty- five will comprise more than 22 % of the population by 2030. Unfortunately, age-associated chronic diseases and conditions are increasing just as fast. It is not likely that there will be a single scientific breakthrough that will extend our life expectancies. Rather Dr. Giuliano believes that life extension will be through a series of small steps including small hermetic challenges to positively tweak our metabolic functioning in a positive direction One such tweak is caloric restriction, intermittent fasting. Others include small exposures to other stressful situation such as cold and exercise

Life span has increased

• Cavemen lived til age 22
• Last year leveling off
• 100 years ago 50
• Today lifespan from birth 80 – 81

Aging

• Universal, biological response
• Every species has a typical lifespan
  • varies by species
  • Lasting minutes to millennia
• Lifespan of an individual is tiny compared to the Universe.
• We won’t live forever
• We can probably expand lifespan to 115
• Can we expand our lifespan to maximal age known (122)
• He believes that genetics plays only 12 – 15 % of contribution to our health
• Epigenetics what activates, turns off and keeps genes in healthy balance

Reasons for increasing life span

• Vaccines,
• clean air,
• water,
• sanitation
• Learned what microbes are
• Fewer people are smoking

European Countries may have a longer life expectancy

Evolution protects the species rather than the individual

• Did not want older people to be consuming resources
• We can hack this
• He believes we improve our health incrementally with a series of small hacks
  • Many incremental things we can do
• The aging programs has many facets. Are many things to do
  • For example what can you do to keep car going – lots of things
  • Greatest achievement is extending life span of auto using total quality management
    • Found out what worked, stayed with it and then move on to something else
      • For example getting up and walking every hour
    • Is not one magic pills
    • You have to work at this
    • Many folks have chronic diseases
    • Does not look encouraging doing what we are doing now

Health is multi dimensional

• So there are many interventions
• Varies by individual
• Use best knowledge available. We are all different

Why are we aging prematurely

• Exposure to too many stresses
  • Too many Chemicals
  • Too much exercise
  • Oxidative Stress
  • Some biological pathways may not function that well
• Epigenetics
  • Relies on methylation
    • Can reverse some of methylation patterns
    • Can reverse aging in selective dimensions.
      • Research on reversing Alzheimer’s and Parkinson’s
        • , Dale Bredesen
        • Pharma anticlonal, mono clonal treatment
      • Aging clocks
        • Hair grey, teeth
      • Zymo research. Tests for different genes
      • PSK-9 inhibitors
        • Prevent Cardiovascular disease by turning of cholesterol in every cell
          • We need cholesterol in every cell for cell walls and hormones
        • Make statins obsolete
        • Traditional pharmacological approach take a pill to manage situation

Stress

• If you don’t use it, you lose it
• If you want to live long you need stress: physical and metal stress
  • Need serious mental and social challenges
  • Hormesis a little bit of stress produces strong stress resistance
  • Need stress: too much can kill you
    • Trigger strong epigenetic response
  • Little bit of radiation is good for us because it upgrades radiation defenses.
    • Tight blood pressure cuff increases blood flow by 40 %
    • Cold stress gets cold in am and pm
      • Activate heat shock proteins and cold shock proteins
      • Hot saunas. Heat shock programs
      • Polar bear swimmers who go under ice
      • Make now angels, then jump in hot sauna
      • Put new soldiers under lots of stress

• Caloric Restriction
  • Stresses metabolic system
  • Activates upgrades certain proteins
  • Suppress pathway MTOR
  • Produces healthy response
  • Increase sirtuins,
  • Increases FOX O gene

Recommendations

• Monitor what makes you bright in the morning and gives you energy
• Monitor what takes energy away
• Start with simple things
  • Respect own body patters of sleep and awake
  • Respect daily circadian clock
• Diet is extremely important
  • He like Mediterranean diet
    • Fruits and vegetables are still alive when you eat them.
      • These cells have stress response
      • These upgrade own stress chemicals.
    • Not too many preserved meats
    • Minimize meats
  • Eat fish
  • He does not believe in a particular dietary protocol
  • Vitamin D 3
  • Fish oils, essential omega three oil
  • Supplements
    • Ashwaganda
    • Ginger
    • Boswellia
    • Curcumin with liposomal and nano technology

Diseases that kill you have. A lot of inflammation

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