Jeffrey Gladden, MD, FACC – 100 is the new 30: Live Young for a Lifetime

100 is the new 30: Live Young for a Lifetime

Aired On: May 17, 2024

Episode Description

We don’t age in a linear way. Aging accelerates exponentially, and virtually all plans that simply focus on eating better, exercise, sleep, stress reduction, hormone replacement, and supplements are a linear strategy to an exponential problem. Dr. Gladden discusses his multifactor approach on how to become fit, strong, mentally sharp, and relationally replete Dr. Gladden discusses approaches in the fields of longevity, health, human performance, and life energy.

One hundred is the New Thirty with Jeffrey Gladden, MD

When we are told we have normal laboratory blood values, that means we are normal compared to 95 % of a very sick population
Our current allopathic medical system is based on treating symptoms, not underlying causes (“sick care”, “disease management”
We should seek optimal health and health longevity
How do we measure how old we are? Are we as old as our oldest organ?

His approach includes a mosaic of different ages and performance measures

There is a disconnect from chronological and biological age: we an live young til an old age
Many companies have different methods to determine biological age
He believes people have a brain age, heart age, lung and kidney ages
We are as young for a lifespan
Ages of drivers of longevity
- DNA aging, methylation aging

How to do this

First realize living young over a lifespan is possible
- There is enough technology so we go down a different aging path than our parents did
- When he is 100 years old chronologically, he wants a thirty year old body and a three hundred year old mind
First step is how do we go back to feeling like we are thirty years old
- His first step was to figure out how good/ fit/ strong he could be he could be
- Obstacles are being married to one’s answers (binary thinking)
  - Physicians tend to have answers only in their discipline
- The issue is not to have the right answers but to have the right questions
  - How good can I be?
  - How do I make 100 the new 30?
  - How do we stay young for a lifetime?
  - How do we crack the code of living well beyond 120?
  - Hayflick limit? (telomere shortening that causes cell death and senescence
- Two targets
  - Guidepost how felt when at best
  - How optimize sense of wellbeing
- He would ask
  - At what age did you feel physically the best in your life?
  - What was going on in your life at that time?
  - How you felt then is transformed into your guidepost
    - This memory is changed into a target
  - Where are you in this process and what cards are you holding
    - He encourages genetic testing to see what cards you are holding
      - New Amsterdam, telex
      - Genes are not destiny, they are only proclivities
      - We can take steps to alter gene expression
    - Where are you in this “game”?
      - This involves testing
        Biological age
        CO2 max
        Brain age,
        lung capacity,
        bone density
        gut functioning
      - then work on these issues
    - simultaneously, a second path is how to optimize sense of wellbeing, equanimity, peace
recommended testing
- cardiovascular function
  - cardiopulmonary exercise test
    - measures status of heart
      - measures heart dysfunction during stress
      - shows where exercise zones are
      - shows how in shape you are,
      - VO2 max (how much blood heart is able to pump)
        The higher this number is, the healthier you are; longer you live less cancer, dementia heart disease
- Resting metabolic rate
  - Wear mask measures how much oxygen consuming and how much carbon dioxide are blowing off
  - Measures metabolic rate inside cells
    - For example, can detect low thyroid although blood thyroid test levels are normal
- Measure thyroid blood labs
- Gut functioning
  - Stool testing, digestive enzyme testing
- Measure hormone levels both in blood and in urine
  - Urine show urine metabolites shows how processing hormones
  - Want to ensure don’t have genetic predispositions that can lead to hormonal cancers
- Test if have cancer
  - Want to pick up predisposition before have cancer
  - By the time cancer shows up on MRI, have many cancer cells in body
  - He looks at tests to look for circulating tumour cells (Greece)
  - Tests to look for DNA fragments from tumour cells
    - Highly sensitive to picking up cancer
  - Need to understand mitochondrial function
    - Mitochondria don’t have telomers, as telomers get short, they signal mitochondria to shut down energy production
    - Can look at ‘
      - might need to examine through different lenses
      - global mitochondrial function,
      - Internal functioning
        Krebs cycle functioning
        electron transport chain
  - Need to know where are with longevity
    - Measure how are optimizing longevity
    - See if are on a trajectory for longevity
      - Make sure everything in order
        
        Gut, heart
Sixteen hallmarks of aging
- Initially address issues that will have greatest impact
- Telomere length
- Mitochondrial age
- Mitophagy
  - Ability of mitochondria to rid destroy old mitochondria and create new mitochondria
- Glycation’
  - Ability to attach sugars to proteins
  - Glycanage
    - looks at different sugars attached to antibodies
    - will determine age of the immune system
    - one form of glycation is hemoglobin A1c which gives measure of glucose attaching to hemoglobin -will give idea of what happened over last 90 days
- cancer potential
  - genetics to look at cancer potential
  - screen for cancer cells, cancer DNA fragment
- ability to repair DNA
- tests to see if DNA is oxidized
- microbiome changes with age
  - stool test (inflammation, bacterial overgrowth, are digesting properly., constituents of bacterial
- epigenetic changes
  - genes can modify to change expression (David Carr’s work out of Harvard
  - DNA methylation
    - has linear pattern with age
    - Status of stem cells, diabetes, immune system
    - Epigenetic rate of aging
      - Truage
      - Where are in longevity game
      - Want to age at a slower rate
- Nutrient testing
- Balance of AMPK, mTOR
  - mTOR
    - activated when well fed
    - where “build new stuff” bone, muscle, cardiovascular strength
    - keeps us young but increases risk for cancer and die sooner
    - activate with substances that increase growth hormone and testosterone
    - peptides for growth hormone release
    - high intensity interval training to increase growth hormone
    - blood cell resistance training
    - hormone replacement to increase testosterone
      - take when on mTOR cycle
    - blood flow restriction resistance training
      - increases growth hormone release
    - No fasting during this period
      - He will eat more liberally
      - Takes amino acids to build muscle , collagen, and protein
    - If are on mTOR pathway all the time, don’t build as much muscle, than if use rapamycin occasionally
  - AMPK
    - Activated by fasting, aerobic exercise, saunas, berberine, metformin (is made from berberine), resveratrol
    - This activates other genetics associated with DNA repair
    - Increase by long distance cardio (run, swim, bicycle riding
    - Fasting
    - Resveratrol (vimea)
    - Rapamycin will block mTOR pathway
    - Fasting
      - Study
        People who ate one meal per day, 80 % increase in mortality in heart disease
        Three meals per day did the best
      - Fasting is helpful – the problem is how we eat when not fasting – can undo all the good
      - Eating can be stressful to metabolize all the calories
      - He recommends eat within a time window eating several small meals so not to tax the digestive system
  - His program
    - He focuses on mTOR pathway for two days and then AMPK for two days
    - Uses testosterone on Tuesday, growth hormone releasing peptide on Tuesday and Wednesday night
    - He reinjects testosterone again on Saturday and growth hormone releasing hormone on Saturday and Sunday night
    - During other days is increasing aerobics training, spermidine to increase autophagy
    - He uses rapamycin 10 mg every two weeks
      - It takes 10 days to get out of system
      - Suppresses immune system if taken every day
      - Upregulates immune system if taken every two weeks
      - He takes testosterone with it
      - For a week after, he does not do anything to activate mTOR pathway
- Autophagy
  - Way to recycle nonviable proteins out of the system
- Proteostasis
  - How make proteins, transcribe proteins, dispose of proteins
    - Need to fold proteins, if not repair or get rid of improperly folded
      - Can measure with transcriptomics and proteomics
- inflammaging
  - Inflammation,
  - Supplements to decrease inflammation
    - Fish oil
    - SPM special proresolving mediators
      - Derivatives of fish oil and 200 times more potent
      - New 15 carbon saturated fatty acid from dolphins
        Activates AMPK
        Downregulates mTOR
- oxidative stress
  - can use molecular hydrogen to balance
- NAD levels
  - Vital for mitochondria function and energy production
  - Decreases with age as enzymes increase that consume NAD
  - Apigenin (comes from parsley) blocks PV38 that consume NAD
- Senescent cell burden
  - Zombie, nonfunctioning cell accumulation’
  - These cells start to secrete inflammatory cytokines
    - Increasing risk for cancer
    - This explains why aging is exponential
- mRNA splicing dysregulation
- Stem cell exhaustion
  - Look through DNA and methylation testing
- Look at alternate communication (no way to measure currently
- Molecular damage to cells (no way to currently measure
- Altered cellular mechanical properties
  - Some cells cannot communicate with nucleus in way are supposed to
Four circles
- Life energy. Psychospiritual 300 year old mind
- Longevity
- Health. Organ systems
- Performance
  - If not training for performance, are getting slower
  - Want flexibility
  - Resistance training, aerobic training
Initial steps can do without tests
- Stop unhealthy habits and foods
- Learn to meditate
  - So are less impacted by things
  - Stress ages. Look at Presidents as they leave the office
- Can focus on major concerns and get those tests from providers

Resonance / vibration with Universe, with God

Here we define our purpose why do we want to live 100 years?
Go down pathway which one resonates with
- Then more connection with higher power
- Then things open up for you