Aristo Vodjani, PhD

Toxins: Pathway to Autoimmunity

 

Episode Description

Up to ten percent of the population has an autoimmune disease, and this percentage is increasing. Dr. Vojdani explains the cause of the increase in autoimmune disease. Environmental conditions contribute approximately seventy percent of autoimmune conditions. Genetics account for only thirty percent. This unrelenting process starts with environmental toxins. Every year, there are 2,500 new chemicals in 6 billion different products. These toxins accumulate in our bodies and bind to our tissues forming a new antigen (that is an unrecognizable substance in the body resulting in a immune response). The immune response initiates inflammation and an autoimmunity response as the body attacks this unrecognizable substance. This sets off a storm of inflammation that can enter the brain causing neurodegeneration in the brain. This can result in depression, anxiety, cognitive decline, memory problems. Toxins in food and the toxins resulting from infection suffer a similar fate.

Previous speakers have pointed out the level of toxins in our food:

  • Some countries will not accept certain US foods
  • 80 % of our toxin exposure comes from meat
  • Countries send their moldy, toxic coffee to the US
  • Gluten causes a fire that sets off inflammation
  • Any digested food leads to inflammation and autoimmunity diseases

Definition of an autoimmune diseases

  • Autoimmune disease occur when body mistakenly attacks its own tissues.
  • Normally the body can differentiate between self and non-self. It is like a computer that develops as a child to learn to differentiate self from non self.
  • An autoimmune disease occurs when this mechanism makes a mistake and attacks its own body

Demographics

  • Autoimmune Diseases affect 53 million through out the world.
  • 7-10 % world population suffer from autoimmune disease
  • 100 different types
  • Autoimmune Reviews seriously on the rise. This is not due to an increase in diagnostic ability.
  • Female to male ratio is 18 – 20:1 in some autoimmune diseases
  • Overall the ratio of autoimmune diseases is 2-3:1 in females (because they have more exposure to toxins with cosmetics
    • They can wear 120 chemicals before they leave the house.

Genetic Component

  • The rise in autoimmune diseases is due primarily to the increase in environmental triggers.
  • The National Institute for Health reports that one third of autoimmune diseases are due to genes: the other two thirds to environmental triggers.
  • In twin studies, if one twin had an autoimmune disease, 30 % identical twins develop an autoimmune disease whereas only 5 % of a non identical twin develops an autoimmune disease
  • The primary environmental triggers are
    • Toxic chemicals
    • Infections
    • Foods that we eat

Example

  • His mother suffered 47 years of rheumatoid arthritis which he believes was caused by gingivitis. None of her ten children developed rheumatoid arthritis.
  • When toxins are released into the blood, the body reacts against these foreign substances by producing inflammatory materials. The bacterial toxins attack joints resulting in the destruction of joints and tissues.

when immune system does not like ità immune disorders including autoimmune

Toxins

  • There are 2500 new chemicals each year
  • There are 6 billion different products
  • tea bags contain 20 different toxic chemicals
  • lemon juice, ketchup, vinegar are acidic and when placed in plastic will dissolve the plastic which goes into food
  • Even water can dissolve plastic
  • Due to simple contact, a piece of salmon in a plastic container absorbs a significant amount of plastic

Env Health Perspective  official J Government

Biphenol A (BPA)

  • Crosses the blood brain barrier, binds to enzymes so the enzymes do not work
  • Science published an article that plastics that were developed after BPA (e.g. BPF3) were as bad as BPA.
  • Plastics compete with the thyroid hormone receptor resulting in thyroid autoimmunity.
  • Any synthetic material bad to health particularly to immune system

Chem I structure BPA and TSH almost identical

Are endocrine disruptors

Hormones play significant role with autoimmunity

BPA interfere with estrogens and progesterones (women

Tetrab fire retardant slow 5 minutes

Tetra cl  dry cleaners

Hg almagam  EU no under 15

Paraben woman

Lfatoin pean

PCB disrupt BBB promote

Formadhlyde

Een paper cups

Any chemical on body.

 

They get into body and combine with tissue form neo antigens

Bind to fat cells

Scary for over 25- 40 years

 

Many scientists think chemicals are in and out

Maybe correct for 80 %  thru urine

Minute amounts of 20 %

TCB a

Tetra bromide B  20.42

Labs measure in urine in blood

97 % had high levels of these chemicals in urine

pee indicates exposure

how much binds to our tissues

bind to tissue mechanism responsible for autoimmune system as it looks foreign

 

Hg in amalgams, fish, water, organic vegetables

 

In Amazon, individuals working in gold mines  developed antibodies against nuclear material (nucleus)

Heavy metals first bind to membrane of cell

Managed to penetrate membrane

Bind to DNA and RNA so our body makes Ab against our RNA, DNA

These are called anti nuclear antibodies

Those who consume fish

Heavy metals 80 % out in pee

20 % into nucleus, destroy cell makes Ab against our RNS, DNA

 

anti nuclear Ab

why?

Eliminate triggers

Be aware, try to consume fish with min toxic chemicals

 

Toxins affect microbiome

He started as microbiologist

Each bacteria loves different types of food

Agar

Rice agar, potato agar, blood agar

You are what you eat.

You are what your mothers ate

When mother pregnant  her diet

Plastic bottles, dental procedure, fish

Affects wiring brain

Natural birth vs c section

Breast feeding vs C section  affect integrity of gut and microbiome

 

Unfortunately, we blame everything on the genes

Articles connect 9 months of pregnancy and mother’s life style

If child exposed to all of these, in the futre will have dm or autoimmune ds most is associated with thos 9 mo, breat feeding , and then diet. When immune system is in the process of developing

 

 

Will have more bad bacteria vs good bacteria

Bad bacteria release toxins affect integrity of gut barrier

Unwanted stuff into blood

Opens BBB

Now fire is in the brainà inflammation and neuro autoimmunity

All affect integrity of gut microbiome.

 

Connection gut barrier vs BBB huge similarity biochemical point of view 75 %

 

Gut microbiome affects and release toxins and open BBB and induce inflammation in brain

Bacteria by releases LPS which are endotoxins open BBB an induce depression

 

Give probiotics significant improvement in depressions

 

LPS from bacteria releasing bacteria called endotoxin

Enterobacters  , shigella, h pylori E coli, salmonella, shigella, klebisella, camplobacteria jejueni, and H pylori

 

Gluten not digested directly open gut barrierà inflammationà open BBB

Certain components of gluten corrs react with brain tissue

Cerebellum

Dr. Kharazian

If make Ab against BPA bound to human tissues if cross BBB can bind with brain tissue such as mylin basic protein, mylen oligodentracyte basic protein

Is a mechanism by binding to our tissues result in cross reactivity and autoimmunity against our own brain tissues

 

Aging  not making enough enzymes cannot digest food

Not enough enzymes

Chemicals such as food coloring our enzymes cannot digest them any more

Immune and cross reaction

Gluten ataxia, food

 

Tandoori chicken has dye attached to it

Tetrazine yellow 8 digest only 80 %

 

Children paint faces, cakes with food colouring  we should learn

Skin is largest organ

½ minute chemicals put on skein are in body

chemical set stage for autoimmunity in the future.

 

Reverse

Go green as much as possible

Organic foods

 

Env health perspectives

Normal kids normal diets

When on organic foods for one week had 20 %

80 % less chemicals

 

Plastic bottles

Cook with Teflon coated materials

Shampoo on hair

Have to educate outselves

 

Detct remove, repair body capacity to deal with this

 

Repair

Broken gut barriers, broken BBB

Have to change the integrity of microbiome

Change diet

Hamburger have more veggies and fruit

Sugar drink less sugar from glass bottle

Bad microbiome loves sugar

Give probiotics

Aa l glutamine n acetylcysteine (converted to glutathione)

 

Detox body

GI tract in blood have regulatory T  T reg regulates immune system

On membrane of T reg have receptors vitamin A a, D and components of cruciferous vegetable  indol 3 carbinol.

Lots carrot juice, fish oil best source vi D

Cruciferous  veg empower T reg takes care of bad microbiome

 

Detect window of opportunity  1 – 10 yrs

Detect as early as possible

Developed antibody assays to detect antibodies as biomarker of autoimmunity of future

at Cyrex Labs

Look at triggers is it food, toxic chemicals, infection

 

Fecal transplant

Replace bad bacteria

Husband over wt inflammation early autoimmune

Gets antibiotic

Introduce with endoscope into SI and colon

After 3-6 months satart to lose wt, inflammation gone, chrons

 

Antacids

½ may have too much acid

½ too little acid give one spoon vinegar QD

antiacids make these worse

 

Summary

daily environmental triggers

infections, toxic chemicals, foods

these three factors affect immune system

immune system mistakenly goes after our own idisaseà autoimmune disease of the future